#5 Yes and yes
Krause MR, Regen SL (2014) The structural role of cholesterol in cell membranes: from condensed bilayers to lipid rafts
Best for: People sensitive to methyl-B12 Those with histamine intolerance or mast cell issues Overmethylators or those with anxiety from methylated vitamins Detoxification support (binds to toxins like cyanide and nitric oxide) Balanced, gentle B12 support Advantages: Body controls conversion rate (less likely to cause overmethylation) Supports detoxification pathways Well-tolerated by most people Longer-lasting in the body than methyl-B12 Potential downsides: Requires conversion (may be less efficient with severe MTHFR mutations) Slightly less direct methylation support than methyl-B12 Can be harder to find in supplements Typical dosage: 1000-5000mcg daily 3
Section staining and microscopy We were granted access to specimens from the network for organ donors with diabetes (nPOD)(36) ( from where we requested glass slides with sections of paraffin embedded pancreas from 7 healthy control donors (6007, 6029,6336, 6134, 6162, 6384 and 6339), 7 donors with type 1 diabetes with retained C-peptide production (6414, 6399, 6362, 6342, 6196, 6240 and 6405), 6 donors with type 2 diabetes (6273, 6108, 6114, 6139, 6189 and 6191) and 6 healthy donors with detected anti-islet autoantibodies (6123, 6080, 6314, 6090, 6147 and 6158, whereof all were positive for anti-GADA, and 6080 and 6158 were positive for anti-mIAA)
Ozempic and Mounjaro are FDA approved for type 2 diabetes and are available only to patients who meet clinical eligibility criteria, as determined by a licensed healthcare provider
